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KMID : 0603820070130030245
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 3 p.245 ~ p.249
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Screening Test of Wild Mushroom Methanol Extracts for Fibrinolytic and alpha-Glucosidase Inhibitory Activity
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Kim Jun-Ho
Yoo Kwan-Hee
Seok Soon-Ja
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Abstract
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We investigated the fibrinolytic and {alpha}-glucosidase inhibitory activity of 55 wild mushroom methanol extracts. Among them, 14 mushrooms showed fibrinolytic activity. In particular, Amanita virgineoides showed the greatest enzyme activity (3.9 plasmin units/ml) by a fibrin plate assay. The fibrinolytic activities of Suillus pictus and Polypolellus varius were 3.8 plasmin units, and the activity of Gomphus fujisanensis was 2.8 plasmin units. Leccinum extremiorientale and Xerocomus nigromaculatus had the same activity with 2.3 plasmin units. In a {alpha}-glucosidase inhibitory activity test, Lactarius sp. showed the greatest inhibitory activity at 97.3%. The {alpha}-glucosidase inhibitory activities of Clitocybe odora, Xerocomus nigromaculatus, Melanoleuca melaleuca, Suillus pictus, and Gyroporus castaneus were 84.3%, 77.9%, 74.6%, 68.7%, and 65.4%, respectively. According to the results, because Suillus pictus and Xerocomus nigromaculatus have strong fibrinolytic and {alpha}-glucosidase inhibitory activities, the two mushrooms will be used as materials for the development of new biofunctional food.
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KEYWORD
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{alpha}-Glucosidase Inhibitory Activity, Fibrinolytic Activity, Wild mushroom
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